Top 7 Most Effective Weight Loss Pills

a large pile of pills on a table

Overweight or clinically obese individuals may benefit from the help of weight loss pills when diet and exercise alone fail to meet their goals. For those of you who have a hard time getting rid of those extra pounds, we have created a list of the most effective weight loss pills out there. The pills presented below are listed in no particular order.

*Speak to your doctor thoroughly, citing your medical history, before taking any weight loss pills.

7. Glucomannan

a box of Glucomannan capsules

What it does: This weight loss pill acts like a sponge, absorbing water and transform it into a gel-like substance. Once you ingest it, this pill remains in your gut and makes you feel full, reducing your appetite. Therefore, you will not feel the need to eat as much as before.

How it is used: If you want to lose weight, you will need to take a small dosage of one gram of Glucomannan, three times per day. This is explained by the fact that the pill expands when getting in contact with water.

Pros: Several studies demonstrated that Glucomannan can help you lose weight (up to ten pounds in five weeks). Still, you need to combine it with a healthy and balanced lifestyle. This pill contains plenty of fibers which will support the life of healthy bacteria from your intestines.

Cons: Some individuals said this pill caused them bloating and flatulence. Also, it might lead to soft stools. You should pay attention not to take it with some other medications at the same time.

6. Hydroxycut

a box of Hydroxycut pills

What it does: This is currently among the most effective weight loss pills in the world, having a history of over a decade. Among other ingredients, it also contains plant extracts an caffeine. These are well-known elements that help individuals lose weight.

How it is used: Specialists recommend you to start by taking small dosages of Hydroxycut and then increase them gradually. For starters, you should take one tablet, three times per day.

Pros: During a clinical study, researchers discovered that Hydroxycut can make you lose around ten kilograms in approximately three months.
Cons: It might cause anxiety, nausea, tremors, and irritability for those of you who are caffeine sensitive.

5. Orlistat

a box of Orlistat Alli weight loss pills

What it does: Treats obesity as part of a low-fat, low-calorie diet. Blocks the absorption of fat into the body by preventing the pancreatic lipase enzyme from breaking down fat in the small intestine.

How it is used: Available over-the-counter as brand name Alli or by prescription under the brand name Xenical. The Mayo Clinic advises that this weight loss pill works best when taken with liquids during meals.

Pros: Proven to show an effective but modest weight loss average of approximately 5.5 pounds more per year than through diet and exercise alone.

Cons: Gastrointestinal side effects may include gas, bloating, or oily stool. Consumers must carefully control the amount of fat intake in their diet while taking this medication.

4. Lorcaserin

a box of Lorcaserin tablets

What it does: Curbs hunger by activating the brain’s serotonin receptors to induce a feeling of fullness.

How it is used: Available by prescription under the brand name Belviq or Belviq XR. It is taken by mouth once or twice per day. Doctors should prescribe in combination with an approved diet, exercise, and behavioral therapy program.

Pros: When combined with diet and exercise, patients studied have shown an average weight loss of 3 to 3.7 percent more than patients who took a placebo.

Cons: Cannot be used with some antidepressants. May cause drowsiness, headache, constipation and is not approved for use during pregnancy.

3. Phentermine-Topiramate

Qsymia purple capsules

What it does: This weight loss pill combines the stimulant phentermine with the anti-seizure and migraine drug topiramate to decrease appetite and increase feelings of fullness.

How it is used: Available by prescription as Qsymia for weight loss in patients with a BMI of 30 or more. Product information may be found at the manufacturer’s website.

Pros: Patients can lose as much as 9 percent of body weight when combined with diet and exercise. In the Anti-Obesity Pharmacotherapy: New Drugs and Emerging Targets study published in 2014 in the Clinical Pharmacology journal, Qsymia patients studied in clinical trials tend to sustain their weight loss longer than patients taking a placebo, up to two years in one study.

Cons: Anti-seizure drugs may cause suicidal behavior. Women who may become or are pregnant should not take Qsymia, as it is linked to a known cleft palate congenital disability. May cause insomnia if taken at night.

2. Bupropion-Naltrexone

a large pile of Contrave blue pills

What it does: Treats addiction response to food by targeting the hunger and reward centers of the brain. Both drugs were previously approved and prescribed to treat addiction.

How it is used: Sold as Contrave by prescription only. Take orally once per day for extended release.

Pros: Clinical trials have shown that 36 to 48 percent of non-diabetic patients studied lost at least 5 percent of body weight. One Obesity Research Trial showed that 55.6 percent of patients lost 5 percent or more of weight.

Cons: FDA has demonstrated concern over possible cardiovascular side effects or long-term damage. Suicidal behaviors have been shown.

1. Forskolin

a box of Forskolin tablets

What it does: It stimulates the process of fat burn by boosting the levels of cAMP. This is a body compound found inside cells.

How it is used: One must take a dosage of 100-250 mg of Forskolin, two times per day. So far, this pill appears to be safe. Those who took it did not experience any side effects.

Pros: It is a clinically-tested weight loss pill and the results were optimistic. Forskolin reduces body fat and increases muscle mass.
Cons: Some individuals involved in the study said they did not perceive any effects after taking the pill. There are just a few studies with limited data of this weight loss pill.

Putting It All Together

Weight loss pills are among the most effective methods you can do to manage your overall health and improve the quality and longevity of your life, besides a balanced diet and regular exercise. Taking the time to research and discuss these weight loss options with your doctor is an important step to take control of your health. Please share your experience with any of these most effective weight loss pills discussed in this article, in the comments section below.

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